The Dutch rider dedicates her victory to Movistar soigneur Gary Baños, who died in a mountaineering accident, and injured compatriot Amy Pieters.
Van Vleuten gets season started the right way with successful GC defense in Spain after also winning the 'Queen Stage' on Saturday.
Van Vleuten wins stage 3 with solo move on summit finish to secure GC lead ahead of final day of racing.
Dutch rider wins from two-up sprint after attacking with Soraya Paladin with just over 10 kilometers to go.
Trek-Segafredo keeps it together for sprint finish despite a late attack from Annemiek van Vleuten and more.
There is a stacked start list for the opening women's UCI stage race of the 2022 season with 13 WorldTour teams set to start.