American team down to five riders as its Giro d'Italia takes another blow.
American squad carries momentum from summer with Giro's open race dynamics offering further opportunities.
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Ecuadoran delivers big win after all eyes have been on EF Pro Cycling's wild jersey since the Giro d'Italia started.
Overall leader Filippo Ganna gave up pink jersey to João Almeida when he dropped back to pace Ineos Grenadier's team leader Geraint Thomas back onto the peloton.
EF Pro Cycling retains overall advantage, with the lead moving from Jonathan Caicedo to Higuita.
Ecuador's Jonathan Caicedo retains the leader's jersey when his EF Pro Cycling squad won Tuesday's opening team time-trial.
EF Pro Cycling's Jonathan Caicedo leads the Tour Colombia 2.1 after the squad's impressive performance in the team time trial. Caicedo has charted a path from rural Ecuador to the WorldTour.