Denise Betsema was the breakout star of the last cyclocross season, but she returned an adverse analytical finding in an anti-doping test at a January World Cup.
Aerts takes World Cup title after Van Aert finishes race disappointed in third.
Slippery, technical course gave Brand second World Cup win of the season as she soloed away from Vos, second, and Worst, third.
Cant slip in final lap disrupts lead group's momentum, opens door for Brand
The UCI cyclocross World Cup returns to America in 2018 with rounds in Madison and Iowa City in September.
Wout Van Aert wins the eighth round of the Telenet UCI Cyclo-cross World Cup in Fiuggi and clinches series title with one round remaining.
With just two weeks until Worlds, Mathieu van der Poel and Sanne Cant dominated Sunday's sixth World Cup cyclocross round in France.