The Naked Factory Racing rider follows up her 2012 win with a victory in Winnipeg.
The rider from Québec rides to victory in the men's race, with Geoff Kabush taking second and Aaron Schooler placing third.
Maghalie Rochette, Mical Dyck, and Leah Kirchmann are all expected to be in the mix this weekend in Winnipeg.
Gagne returns to 'cross after four years away from the discipline, and he's expecting to make a splash at Canadian nationals this month.
Garrigan and Pendrel prevail in Winnipeg to earn maple leaf jerseys in Canadian 'cross nationals
The 21-year-old Canadian is having her best 'cross season yet and is shooting for victory at nationals this weekend
Kabush looks to secure his sixth Canadian cyclocross national title in Winnipeg, and talks about his motivation to stay competitive
Top cyclocrossers head to the Canadian prairie for three days of racing on a downtown course
Peter Kraiker shoots the 2011 Canadian cyclocross national championships.