The Orica-Scott rider launched an attack with 4.6km to go and soloed the rest of the way up the mountain.
Wiggle-High5 has two aces in former Flanders winner Longo Borghini and Belgian D'hoore, plus Audrey Cordon-Ragot could be a wildcard.
Elisa Longo Borghini's victory at Strade Bianche, the first women's WorldTour race of the season, had much drama attached to it.
Italian Elisa Longo Borghini (Wiggle-High5) claims a sprint victory at Strade Bianche Women in Siena, Italy on Saturday.
The reigning world champion breaks free from the leading group inside the final kilometer to win the stage.
Wiggle-Honda satisfied with its showing at the Aviva Women's Tour as young talent continues to learn and notch big results
Flèche Wallonne organizers added a new climb near the finish of Wednesday's race, but the race could still be decided on the Mur de Huy
In the absence of five-time winner Vos, all eyes will be on world champ Ferrand-Prévot who faces challenges from several big names
Neal Rogers considers the riders who succeeded and those who came up short at Belgium's biggest race, the Tour of Flanders
Elisa Longo Borghini takes the long road from a wheelchair to the top step of the podium at the Tour of Flanders